No sperm antigens

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Effectiveness of sperm washing by discontinuous density gradient centrifugation to remove antibodies bound to the sperm membrane. We evaluated the effectiveness of sperm washing using the discontinuous two-layer density gradient centrifugation method to remove antisperm antibodies attached to the sperm surface. We prospectively enrolled sixty-six men with unexplained infertility who were seeking evaluation.

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Alternative titles; symbols. Naz et al. The antigen, called fertilization antigen-1 FA1 by them, is a glycoprotein of 23 kD in the monomeric state that has a ligand activity for ZP3A of oocyte zona pellucida and causes a reduction in fertility of actively immunized female rabbits.

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Immunologic Infertility. Lowering ASA titres in infertile couples using immunosuppressive agents resulted in conception, therefore ASA's are a cause of infertility. InHenle discovered the organ-specificity of anti-sperm antisera and the regional nature of sperm antigen distribution.

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Systems used to automatically annotate proteins with high accuracy:. Select item s and click on "Add to basket" to create your own collection here entries max. Manual assertion based on experiment in i.

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Antisperm antibodies are antibodies produced against sperm antigens. ASA can be detected in ejaculate, cervical mucus, follicular fluid, and blood serum. ASA can arise whenever sperm encounter the immune system.

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Antisperm antibodies ASA may be a reason of infertility in some individuals. They may affect pre- as well as post-fertilization stages of the reproductive process. There is ongoing progress in the identification of sperm antigens related to fertilization.

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Alternative titles; symbols. Cytogenetic location: 17q SPAG5, or astrin, is required for maintenance of sister chromatid cohesion and centrosome integrity during mitosis Thein et al.

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Research Article Free access Find articles by Witkin, S. Find articles by Zelikovsky, G.

Purpose: The expression and role of sperm protein antigen 17 SPA17which has been confirmed to be immunogenic, in breast cancer remain unclear. We examined the expression of SPA17 in breast cancer and assessed its effect on patient prognosis and its function in breast cancer development. Correlation of SPA17 expression with the patients' clinicopathological parameters and overall survival was assessed. The function of SPA17 was also explored.

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